Full time
Washington University in St Louis
St. Louis, MO, USA
Scheduled Hours 40 Position Summary The Miriam Kim Lab studies methods to manipulate immune cells for treatment of hematologic malignancies. We work at the intersection of hematopoiesis, immunology, cancer biology, stem cell biology, and gene engineering. We are seeking motivated individuals to assist with studies investigating the optimal host environment to support chimeric antigen receptor (CAR) T cell therapy. CAR T cells are genetically engineered immune cells that are used to treat patients with hematologic malignancies such as leukemia, lymphoma and multiple myeloma. While CAR T cell therapy has demonstrated impressive success, many patients do not benefit from treatment, and so we are actively looking for ways to improve outcomes. The successful candidate(s) will conduct preclinical studies using mouse models to assess the effect of immunomodulatory agents on CAR T cell expansion, toxicity and anti-tumor activity and their mechanism of action. Prior research...