Moderna, Inc.

Job Title Principal Scientist, Process Development (Expression Systems) Job Function Process Development Location [TBD] Level [TBD] Overtime Eligible [TBD] Relocation Eligible [TBD] Immigration Sponsorship Eligible [TBD] Role Type Full-Time EEO Job Code [TOTAL REWARDS] JOB DESCRIPTION The Role Moderna is seeking an Individual to lead host strain, vector, and expression system strategy for E. coli-based production of recombinant enzymes, plasmids, and related biological materials supporting Moderna’s technology platforms and pipeline programs. This role owns the front end of microbial production: designing, building, screening, and selecting host/vector/expression systems that enable high-performing, scalable, and robust upstream processes. The successful candidate will bring deep expertise in microbial genetics, molecular biology, expression-system design, screening workflows, data-driven construct selection,...

The Role The candidate will be the frontline partner for Operations—owning day-to-day user support for manufacturing digital systems and implementation of changes and continuous improvements across Moderna’s manufacturing network. You will triage and resolve incidents, coach users on best practices, and keep production running smoothly in a GMP environment. This role will be an ideal opportunity to develop a broad knowledge base in the biopharmaceutical industry as there will be exposure to plasmid, drug substance, and drug product processes in addition to novel individualized therapies. The scope of the role will also cover many layers of manufacturing digital technology enabling which will help develop a broad experience base in process automation and recipe design. Primary systems in scope include Syncade (MES), Apprentice Tempo (MES), Aveva SCADA Platform, DeltaV (automation/PCS), the Aveva PI System, and Wonderware (SCADA / PCS), with collaboration across adjacent...

The Role Moderna is seeking an Associate Director, Process Development to lead upstream/fermentation process development for E. coli-based production of recombinant enzymes, plasmids, and related biological starting materials critical to Moderna’s technology platforms and pipeline programs. This role translates strain, vector, and expression-screening outputs into robust, scalable, and manufacturable processes, with responsibility for microbial fermentation, cell banking strategy, scale-up/scale-down, process characterization, technology transfer, and CMC support. The successful candidate will bring strong technical judgment in E. coli physiology and fermentation engineering and will partner closely with strain and expression screening, downstream purification, analytical development, quality, manufacturing, and CMC teams. Here’s What You’ll Do Lead upstream/fermentation process development for E. coli-based production of recombinant enzymes, plasmids, and...

The Role In this role, the Logistics Specialist will ensure GMP compliance throughout Logistics operations. Maintain a safe work environment. Act as a key knowledge point for expertise and leadership in supply chain processes and principles for inbound operations, inventory management, outbound operations to support Norwood Site. Drive key projects and improvements to closure to ensure processes are continuously improved within Logistics. Play a key role in training team members and any quality events to support compliance across Logistics. Here's What You’ll Do Drive compliance and identify any compliance gaps through quality event support and execution. Ensure that Moderna’s Quality Policy and Quality Management System is established and followed. Implement preventive and corrective actions. Supply Chain Logistics systems subject matter expert in digital systems including SAP, Maximo, Veeva, Kneat, and others. Support Supply Chain Logistics projects and...

The Role Moderna is seeking a highly skilled and motivated Individual to develop stable, fit-for-purpose enzyme formulations for DNA template manufacturing in support of Moderna’s mRNA medicines portfolio. This lab-based role will design and execute formulation, stability, compatibility, and use-condition studies for enzymes used in DNA manufacturing workflows. The work will translate enzyme performance needs into practical formulation compositions, storage conditions, and handling instructions that preserve activity, consistency, and process performance. The Candidate will work most closely with enzyme process development and analytical development to define formulation requirements, measure enzyme performance, and troubleshoot stability or activity losses. As formulations mature, this individual will provide technical inputs to tech transfer formulation process into manufacturing with clear material attributes, handling controls, and documentation. Here’s What...

The Role The Infectious Disease Department is seeking a self-motivated and adaptable Individual with strong experience working with murine models and in vivo related techniques to support the development of novel vaccines and therapeutics. This position will contribute across all IDR programs through the performance and development of in vivo based experiments in biosafety level 1 and 2. The candidate will support the IDR comparative medicine team interfacing with multiple functional teams within IDR. The individual will help to ensure the accurate and quality execution of in-vivo based experiments. Here’s What You’ll Do Carry out technical procedural work including dosing (all major routes including intravenous, intraperitoneal and intramuscular) and collection procedures (especially blood and tissues) with laboratory animal species with expertise in mice. Ability to understand and operate rodent anesthesia systems and other specialized equipment such as common...

The Role: In this role, you will primarily focus on managing the analytical control strategy to support large-scale process development and optimization for plasmid DNA, cell-free DNA and enzymes. Responsibilities include driving analytical control strategies and associated deliverables, such as test method development, optimization, pre-qualification, qualification, and validation; specification setting; and the timely initiation of IPC, release, characterization testing and stability studies. The role will also support investigations related to release and stability data. You are expected to work in a highly collaborative, cross-functional team environment, and interface with different departments as well as technical and operational teams. The individual must thrive in a fast-paced environment with high expectations. Integrity, ability to pay attention to detail and troubleshoot, curiosity, collaborative spirit, respect for people, exemplary work ethic and setting the bar...

The Role We are looking to hire a ServiceNow Development Engineer, who brings strong technical expertise, a mindset that embodies the unique Moderna Mindsets, and a passion for delivering the best digital experience to our employees. You will join our team and be responsible for developing and supporting our ServiceNow platform, driving automation, and optimizing business processes. You will help us deliver more value from our existing ServiceNow capabilities and help us grow the platform and digitize departments across Moderna. Here’s What You’ll Do Leverage knowledge and experience to deliver end-to-end solutions on the ServiceNow platform Responsible for the development, core configuration, and technical expertise of ServiceNow platform capabilities, including ITSM, ITOM, ITAM, HRSD, and PA. Design, create, and configure Business Rules, UI Policies, UI Actions, Client Scripts, and ACLs, including advanced scripting of each (including Service Portal)....

The Role: The candidate in this position will be responsible for designing, implementing, maintaining, and supporting integration solutions that enable reliable data exchange across multiple enterprise systems. This role requires close collaboration with stakeholders across business and technical functions to ensure that integrations meet functional requirements, are technically sound, and align with Moderna’s architectural and compliance standards. The ideal candidate will have experience with integration platforms, enterprise applications, infrastructure concepts, and operational support. The role also includes responsibilities for monitoring and improving the integration environment to ensure performance, reliability, and scalability. Here’s What You’ll Do: Analyze business and technical requirements to design integration solutions aligned with enterprise architecture standards. Develop, test, deploy, and document system integrations between cloud and...

The Role: The candidate in this role will be based at the Norwood MA site and will be responsible for preparing and overseeing CMC and Quality related agency correspondence and regulatory applications, as well as govern CMC submissions and regulatory compliance support for the development of global products. This position will lead and support all regulatory activities to provide high quality CMC sections of regulatory documentation. The candidate will need to successfully manage multiple projects in a fast and results-oriented environment to deliver on bringing a new generation of transformative medicines for patients. Here’s What You’ll Do: Support effective CMC regulatory strategies for submissions (e.g. IND/CTA/BLA/MAA) and identify regulatory risks Provide guidance for regulatory CMC aspects of product development projects Review documents for submission-readiness, to ensure that all submissions conform to health authority guidelines Contribute in...

The Role: Joining Moderna means advancing mRNA science to transform medicine. Work with exceptional global teams on a broad pipeline and build a career that makes a real difference for patients. Moderna is strengthening its presence in Norwood, Massachusetts, a cornerstone of our manufacturing and operational excellence. Our Norwood campus translates mRNA science into scalable impact, supporting the global delivery of our medicines. We welcome talent ready to drive innovation and make a meaningful difference for patients worldwide. In this role, you will play a critical part in maintaining and optimizing Moderna’s Maximo system, ensuring data integrity and operational efficiency across site activities. You will act as a key enabler of digital transformation, combining system expertise with AI-driven approaches to improve workflows and decision-making. This is a hands-on, site-based role where precision, continuous improvement, and technical curiosity will...

The Role: In this role, you will play a crucial part of our manufacturing operations, supporting the operation of our cutting-edge GxP manufacturing systems. These systems include, but are not limited to, Aveva System Platform, Rockell Automation ControlLogix, DeltaV, Syncade, Apprentice Tempo, and Aveva Pi Historian. You will be at the forefront of our mission to deliver mRNA therapies to patients worldwide, using your expertise in automation to ensure the smooth operation of our manufacturing processes. Your work will directly contribute to the production of therapies that have the potential to transform the lives of patients. Here’s What You’ll Do In this role, your responsibilities will include: Troubleshooting complex issues within our GxP Process Automation Systems, i.e. DeltaV or Allen-Bradley programmable logic controllers. Maintaining and sustaining a culture of compliance both in how we design solutions and in how we run and maintain operations....

The Role The individual in this position will be responsible for maintenance and repairs of GMP/non-GMP process and support equipment. This position will also support troubleshooting, investigations and reliability engineering for GMP/non-GMP process and support equipment. This position will be the first responder to equipment issues and must follow through to ensure resolution by either performing the work or directing the activities of service providers. Here's What You’ll Do Perform preventative and corrective maintenance activities including simple calibrations as directed by schedule on all process equipment and systems, with established procedures and/or approved practices. Lead efforts in developing remediation for follow-up and emergency work. Troubleshooting on equipment and systems, including development of remediation activities for issues with multiple systems and equipment and repair malfunctioning equipment. Work with equipment owners/engineers...

The Role: Joining Moderna offers the unique opportunity to be part of a pioneering team that's revolutionizing medicine through mRNA technology, with a diverse pipeline of development programs across various diseases. As an employee, you'll be part of a continually growing organization, working alongside exceptional colleagues and strategic partners worldwide, contributing to global health initiatives. Moderna's commitment to advancing the technological frontier of mRNA medicines ensures a challenging and rewarding career experience, with the potential to make a significant impact on patients' lives worldwide. As a Technician III, Maintenance, you will play a critical role in the operational reliability of Moderna’s manufacturing and support infrastructure in Norwood. You’ll lead hands-on activities for preventive and corrective maintenance, while serving as the primary first responder for equipment-related issues. Your expertise will ensure the smooth operation of...

The Role: Moderna is seeking a highly motivated, detail-oriented, and adaptable candidate to join the Infectious Disease Research (IDR) Virology team. This role will support the development of mRNA-based vaccines and therapeutics across preclinical and clinical programs through the execution of virology and cell-based assays. The successful candidate will contribute to generating high-quality, decision-enabling data to support key program milestones, working in a fast-paced and collaborative environment. This position requires strong experimental rigor, the ability to manage multiple priorities, and a commitment to delivering data with speed, integrity, and reproducibility. This position will work closely with scientists across research, translational, and clinical teams, as well as interface with internal and external collaborators, to advance multiple parallel programs. Here’s What You’ll Do: Culture and maintain diverse mammalian cell lines and primary cells...

The Role Moderna is seeking a highly motivated computational scientist to join a collaborative, multi-disciplinary, and fast-paced team supporting computational biology across platform research, therapeutic areas, INT, and development. This role is responsible for mRNA sequence design, analysis, visualization, and interpretation of complex biological datasets, with a strong emphasis on enabling sequence engineering workflows and improving the tools that support them. The successful candidate will contribute directly to mRNA sequence design sequences and projects while also advancing the computational methods, analyses, and internal tools used by the team. This role sits at the intersection of sequence design, data analysis, and scientific computing, and will partner closely with cross-functional groups to support both day-to-day platform needs and broader sequence engineering efforts. Here’s What You’ll Do Conduct mRNA sequence optimization to support platform mRNA...

The Role This position requires a highly skilled and motivated scientist to support and advance the Flow Cytometry Core within the Research Analytics team. This role is critical to enabling high-quality, high-throughput cytometry workflows that support both exploratory and translational research across Moderna’s pipeline. In this role, the individual will operate at the intersection of scientific expertise and project execution—leveraging deep knowledge in flow cytometry while owning the planning, coordination, and delivery of cytometry-based workstreams across multiple programs. Success in this role requires the ability to translate complex biological questions into executable strategies, while managing timelines, priorities, and stakeholder expectations in a fast-paced, matrixed environment. Depending on experience of the candidate, the individual will contribute as a technical expert or lead multiple parallel workstreams, driving assay innovation, operational...