Vertex Pharmaceuticals

Job Description Director, HR Business Partner We are seeking a strategic, influential, and agile HR Business Partner Director to lead talent strategies for key G&A functions at Vertex. This Director will play a critical role in achieving the vision of enhancing leadership, driving innovation, enabling top-tier execution, and integrating technology to achieve superior performance across a diverse development pipeline. This role will serve as a trusted advisor to G&A leaders and their teams, shaping organizational design, culture, and workforce strategies that enable innovation, execution and long-term success. Reporting to the Lead HRBP for the G&A Functions, this individual will sit on functional leadership teams and play a critical role in driving enterprise-wide HR initiatives and change leadership, enabling organizational effectiveness across clinical development functions. This role shapes and executes talent strategies that strengthen leadership, enable...

Job Description General Summary: The Director, Marketing is accountable for understanding the market landscape and Vertex's position within the market, leading business activities aligned with performance goals of the portfolio, and tracking performance against those goals. As a people manager, this role may have financial accountabilities and human resource responsibilities for assigned staff and teams. Key Duties and Responsibilities: Partners with brand/team-lead to shape the brand strategy and brand life-cycle activities Directs the development and implementation of strategic and tactical plans for assigned product Provides input into forecasting assumptions Generates and consolidates key insights across HCPs and patient stakeholders (through market research, ad boards, etc.) and makes strategic recommendations to advance performance against goals Develops strong partnerships with cross-functional team to support business goals Evaluates ROI for...

Job Description General Summary: Cell, gene and biologic therapies are rapidly growing parts of Vertex Pharmaceuticals, where research, development, and clinical manufacturing are highly integrated together at our new R&D site in Boston Seaport. Vertex is seeking a talented individual to join our Process Development team to support media development and optimization efforts. The focus of this position is to support advancement of the innovative stem cell culture medium development and optimization for cell and gene therapy applications. This position will collaborate with cross functional teams to advance media optimizations to enable process scaling, cost of goods reduction, and process robustness improvement through fundamental process understanding. The ideal candidate has deep expertise in media development and optimization, fundamental cell culture process understanding, thrive in a fast-paced environment and proven ability to perform under pressure. The...

Job Description General Summary: Vertex is seeking a talented team member to join our Global Commercial Strategy (GCS) team and work on strategic planning for povetacicept. Pove is a pipeline in a molecule with our first launch in IgA nephropathy followed by additional indications. The associate director, strategic planning will be responsible for driving strategy and planning across pove commercialization, delivery of high quality executive level presentations and independently lead marketing projects. Key Duties and Responsibilities: · Driving key executive committee deliverables including competitive tracker and implications · Cross-indication presentations, EC/CC/DST/town hall deck support · Driving agenda and managing the global-us-international commercialization team including follow ups, building alignment and ensuring team is accountable for deliverables · Multi-indication and lifecycle budget planning and management · Lead customer panel for...

Job Description As the Sales Planning and Incentive Compensation, Associate Director you will be responsible for the administration, execution, and delivery of our Sales Planning & Incentive Compensation (IC) services. This includes the Power BI field reporting platform management, sales team alignments, customer targeting, and incentive compensation deliverables. You will be a strong collaborator with the business unit teams to proactively recommend sales planning and IC strategy to ensure alignment with brand objectives, as well work with internal team members, vendors, and provide individual work contribution in the delivery of these services to meet business expectations and on-time, quality deliverables. This is a hands-on role and will require both tactical experience and expertise in pharmaceutical sales planning, field reporting, IC, and data management to ensure the “end-to-end” planning and delivery of all sales planning and IC services. Key...

Job Description Vertex is growing at a rapid pace with challenging and exciting opportunities for motivated professionals who are keen to contribute to the Vertex mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our finance function is integral to achieving our company’s strategic goals, providing critical insights and analysis in support of decision-making across the organization. By joining our function, you will become part of a fast-moving, forward-thinking team to support the ongoing growth of a leader in the biotechnology industry. The Director of FP&A, DST Finance is a key member of Vertex's Financial Planning & Analysis organization, providing financial direction and strategic insights to cross-functional leaders. This role will partner closely with Disease Area Executives for assigned Disease Strategy Teams (“DSTs”) to help define and deliver against our goals. This role will provide...

Job Description General Summary: Vertex is seeking a talented individual to join our Process Development team as a Scientist. The primary focus of this role is to lead and manage the execution of development studies for a cell-based drug candidate designed to treat diabetes. This is a full-time position based in our Boston, MA facilities, with occasional weekend work required. The Process Development group offers a fast-paced and high energy environment. The right candidate will be a subject matter expert in bioprocess engineering and have a solid technical operations background. Key Duties and Responsibilities: Design and execute experiments to develop robust manufacturing processes for cell therapy products and implement to support programs in clinical development. Mentor team of bioprocess scientific associates who will work closely together within a highly matrixed, cross-functional team to deliver program goals. Communicate effectively between...

Job Description This is a Hybrid position requiring 3 days a week in our Boston office We are seeking an experienced engineering leader to build and operate Vertex's enterprise Knowledge Graph and Semantic Layer: the unified, navigable representation of Vertex's data, concepts, and relationships that AI agents and analytical systems traverse to reason over our business. Vertex Pharmaceuticals is in a transformational period, and the AI team is at the center of our AI-first strategy, delivering AI solutions that empower executives, researchers, and business users to make faster, more confident decisions. As part of the Vertex Data Engineering team, you will lead the Knowledge Graph & Semantics function within Knowledge & Grounding. Your team builds the graph that connects Vertex across clinical, research, regulatory, and commercial domains, and the AI semantic layer that defines the business meaning, metrics, and dimensions that sit on top of it. The capability...

Job Description General Summary: The Principal Scientist/Engineer, Manufacturing Science and Technology (MSAT) – Biologics & Cell Therapy is a key technical role within the Commercial Manufacturing and Technology Operations (CMTO) organization. This position supports late‑stage clinical and commercial programs across the Vertex Biopharmaceutical Sciences and Manufacturing Operations (BSMO) network, with a focus on manufacturing process support, lifecycle management, and technical execution for biologics. Based at the Boston Seaport site, this role partners closely with cross‑functional internal teams and external manufacturing partners to ensure robust, compliant, and scalable manufacturing processes that enable reliable clinical and commercial supply to patients. Key Responsibilities Provide MSAT support across biologics manufacturing processes , spanning development, technology transfer, validation, and commercial lifecycle management. Plan,...

Job Description General Summary: The Quality Product Complaints Associate Director is responsible and accountable for providing quality oversight of the Product Complaint Quality System and the Global Recall and Defect Notification Systems. This role will support quality activities associated within the Compliance team and will partner with various internal and external cross-functional teams including Global Patient Safety, Supply Chain/Trade and Distribution, Medical Information, Guidance and Patient Support, Quality Assurance, Contract Manufacturing Organizations, and external Call Centers. The Associate Director also drives continuous improvement in Vertex quality processes and governance to assure Vertex remains adherent to regulatory expectations and supports QA operational quality oversight and management of complex issues. The role operates with a high degree of autonomy and is expected to influence decision-making, drive risk-based outcomes, and contribute to the...

Job Description This is a Hybrid position requiring 3 days a week in our Boston office We are seeking an experienced AI engineering leader to build and operate Vertex's Agent Intelligence layer: the memory, personas, skills, and flagship agent experiences that make every Vertex AI agent grounded, consistent, and effective. Vertex Pharmaceuticals is in a transformational period, and the AI team is at the center of our AI-first strategy, delivering solutions that empower executives, researchers, and business users to make faster, more confident decisions. As part of the Vertex Data team, you will lead the Agent Intelligence function within Knowledge & Grounding. You will own the four primitives that all Vertex agents are built from: agent memory (personal and organizational), personas as code, skills (atomic tools and higher-order compositions), and the flagship agents that put those primitives to work on Vertex's hardest use cases. As the Director of Agent...

Job Description General Summary: Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA to lead the Materials Development Group. The Material Science Senior Director will support Vertex's drug development programs through a specialized depth and breadth of knowledge of various relationships between materials properties, pharmaceutical processing conditions, and final product performance and quality attributes. The successful candidate will have a proven track record of applying specialized knowledge in solid state science and engineering principles and be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the successful development and scale-up of drug substance and drug product candidates. Key Duties and Responsibilities: Lead a team responsible to: Design experiments to discover and characterize all aspects of solid form discovery and...

Job Description General Summary: The Administrative Assistant provides office/business support to department and generally reports directly to a(n) Associate Director, Director or Senior Director-level manager. Key Duties and Responsibilities: Schedules meetings, secures conference rooms and orders catering for assigned personnel Serves as a departmental resource for Vertex's internal technologies (i.e; Procurement, SharePoint, Concur, Vertex U, VLearn, etc.) Assists with booking flights/hotels and completing expense reports for assigned personnel Based on established departmental procedures, prioritizes and addresses requests for appointments, e-mails and telephone calls; handles routine and straightforward requests and routes advanced items to more senior personnel Processes group purchase orders, invoices, and contracts Assists with visitor registration, including pre-registering and escorting visitors Assists with onboarding of new...

Job Description General Summary: The incumbent will work cross-functionally with colleagues in the BSMO/CMSC, Regulatory, Quality and R&D of Vertex on the design of processes and technologies required to produce aseptic and/or low bioburden drug products to successfully commercialize an exciting and diverse portfolio of innovative pipeline programs. In addition, the successful candidate will support the implementation of risk-based design and controls for low bioburden process operations for production of drug substance/intermediates for manufacturing. Key Duties and Responsibilities: Provide technical input into environmental/facility/process monitoring program deviations and contamination events to determine impact to batch disposition and design/implement effective corrective and preventative actions to prevent future disruptions. Strong collaboration in the resolution of manufacturing investigations related to aseptic control events Support the...

Job Description General Summary: Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA. The successful candidate will be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the successful development and scale-up of drug substance and drug product candidates. Excellent leadership, interpersonal, and organization skills as well as a high level of technical aptitude and creativity are required for success in this position. Key Duties and Responsibilities: Be responsible for leading and developing a cross-functional team of engineers and scientists in defining, developing, and demonstrating viable, multi-step syntheses for the robust manufacture of small-molecule or oligonucleotide active pharmaceutical ingredients, spanning all phases of clinical development through to commercialization and launch Lead drug substance process development...

Job Description General Summary: The Associate Director, Commercial Strategy is responsible for supporting the strategic direction for the Strategic Customer Engagement team by defining priorities, sequencing initiatives, and framing the “why” behind commercial focus areas aligned to Pain BU objectives and enterprise strategy. This role operates above field execution, focusing on strategy formation (what the organization should prioritize and why) while ensuring intentional coordination with strategy translation efforts. The role translates business goals, market insights, and leadership expectations into clear strategic recommendations, frameworks, and narratives. It partners closely with cross-functional and field operations leaders to ensure strategic intent is clearly communicated and effectively handed off for execution. Key Duties and Responsibilities: Lead commercial strategy formation for the SCE team by defining organizational priorities, sequencing...

Job Description The Director, Global Regulatory Affairs Process Excellence & Transformation leads complex, cross-functional operational excellence initiatives across Global Regulatory Affairs (GRA). The role is responsible for identifying, designing, and implementing process improvements that enhance efficiency, consistency, and quality across GRA processes. As a key member of the GRA Process Optimization Network (GPON), this role consults with cross-team representatives to diagnose operational challenges and deliver scalable, sustainable solutions. The Director applies deep subject-matter expertise and hands-on operational excellence experience to shape objectives and drive transformation aligned with GRA and corporate goals. This is a Boston based, hybrid position requiring 3 days/week onsite. Key Duties & Responsibilities: Lead complex GRA process improvement and transformation initiatives using structured operational excellence methodologies....

Job Description General Summary: The Strategic Accounts Lead (SAL) is part of the health system/IDN field team for the US Pain Business Unit, supporting the brand JOURNAVX, a highly selective inhibitor of NaV1.8 that targets pain signals where they start. This role will focus on the highest-priority IDN, GPO, and GPO aggregate accounts in IL, IN, and MO, and report to the Director of Strategic Accounts - Central Area. The name for the SAL region is East Central. An ideal candidate would reside in the Chicagoland, Indianapolis, or St Louis areas. Travel is 60% -70%. Key Duties and Responsibilities: Develop engagement strategy and account plans to ensure success with target IDNs, GPOs, and GPO aggregate accounts Engage with IDN, GPO, and GPO aggregate account leadership, formulary decision makers, and population health stakeholders to ensure timely access and contracting, support product uptake, drive systemic change, and pursue creative partnerships, as...

Job Description General Summary: Vertex Pharmaceuticals is seeking a research scientist to join the analytical development, cell and gene therapy team. This scientist is expected to serve as a key contributor in expanding our proteomics mass spectrometry characterization capabilities for supporting cell and gene therapy program development. The primary focus of this role will be on proteomics analysis for stem cell differentiation and leveraging multi-omics tools to achieve deeper understanding of cell therapy products. Extensive hands-on experience in liquid chromatography-mass spectrometry-based proteomics is required. The individual in this role will collaborate closely with research, process development, manufacturing, regulatory, and quality to develop and innovate Vertex's next generation cell and gene therapy products. Key Duties and Responsibilities: Provide hands-on support for mass spectrometry-based proteomics characterization and perform biological...

Job Description Role Summary Vertex is seeking a Principal level Analyst in the AI Program Management team to lead the development and execution of enterprise AI capabilities that improve business processes, enhance operational efficiency, and deliver measurable value across the organization. This role will focus on AI products that support employees across the enterprise, including digital assistants, agentic orchestration of end-to-end business processes, and other intelligent workflow solutions. Working closely with business stakeholders, technical teams, and product leadership, this individual will define product requirements, shape scalable AI-driven capabilities, and lead the delivery of solutions that enable more connected, efficient, and intelligent ways of working. The ideal candidate is a strategic product leader who excels at translating complex business needs into practical, scalable AI solutions. This person thrives in cross-functional environments and has...

Job Description General Summary: Reporting to the SVP of Research and Site Head of Boston and Seattle Research, the Chief of Staff (Project Management & Strategic Operations Director) is a leadership role that sits on the Boston and Seattle Research Leadership Teams and champions functional and cross-functional project management excellence across Vertex. The incumbent is expected to apply deep Early Discovery and Research subject matter expertise in project and process management to identify opportunities, shape objectives, and drive execution of key Research and corporate priorities. This role focuses on achieving operational excellence in the research organization, enabling site and cross-functional teams to execute with rigor, clarity, and excellence while supporting site-level strategy, operations, and change. Key Duties and Responsibilities: Provide strategic and operational, cross-functional project and program leadership in support of Research and site...

Job Description General Summary: The Associate Director of GCP Operational QA performs advanced GCP Quality Assurance oversight and management activities of clinical trial operations and applicable vendors, to ensure Vertex trials are conducted in accordance with Good Clinical Practice (GCP) guidelines, applicable regulations, protocols and Vertex policies and procedures and quality standards as set forth in the Quality Management System. These activities include the development and execution of study level audit plans, accurately identifying and communicating compliance risks and overseeing action plans to mitigate risks, monitoring and trending of quality risks, issues and compliance metrics, investigation and CAPA management and proactive inspection readiness activities. Key Duties and Responsibilities: Serve as a key technical resource for the GCP clinical execution function with responsibility of assuring quality risk management/ mitigation and adequacy and...