Full time
Moderna, Inc.
Cambridge, MA, USA
The Role Moderna is seeking a Principal Scientist to support the AI-enabled design of de novo antibodies and binder modalities across diverse discovery programs. This is a hands-on, highly technical role for an experienced protein designer who can build and operationalize agentic AI design frameworks and translate modern generative methods into validated binders. This position is strategically important to Moderna’s ability to initiate and execute multiple competitive binder programs in parallel. As a Principal Scientist, you will also mentor other designers and act as a visible scientific agentic AI design resource across the organization. This role offers a rare opportunity to invent how AI-designed binders function in vivo as part of mRNA therapeutics: as stand-alone biologics, targeting modules, or components of next-generation multi-protein systems. The Principal Scientist will work closely with and report to the Senior Director, Computational Design and In Vitro...

