Full time
Washington University in St Louis
St. Louis, MO, USA
Scheduled Hours 40 Position Summary Our current project is to understand the mechanisms underlying chronic inflammation in the progression of pre-cancerous states in the stomach and pancreas to cancer. We take a multi-focal approach to uncovering these mechanisms, relying on experimental systems in mice and from patient-derived gastric biopsies and gastric/pancreatic tumor resections. We apply transcriptional (i.e., single-cell and T cell receptor RNA sequencing), molecular (siRNA, CRISPR-Cas9), immunohistochemical, organoid, flow cytometric, and in vivo (i.e., mouse models) methods to develop new insight into the evolution of pre-cancerous stages to malignant lesions in the stomach and pancreas. This position will specifically focus on processing blood, gastric biopsies, pancreatic fluid collections, and gastric/pancreatic tissue resections for downstream transcriptional and flow cytometric analyses. In addition, the candidate will be expected to isolate, derive, and...


