Institute of Data
  • Learn Practical AI Skills
  • Find Jobs
  • Career Consultation
  • Job Alerts
  • Post a Job
  • Employers
  • Sign in
  • Sign up
  • Learn Practical AI Skills
  • Find Jobs
  • Career Consultation
  • Job Alerts
  • Post a Job
  • Employers

58 principal scientist jobs found

Refine Search
Current Search
principal scientist Massachusetts
Refine by Specialisation
Engineering - Software  (24) Architects  (6) Business & Systems Analyst  (5) Consultants  (4) Management  (3) Developers & Programmers  (2)
Refine by Job Type
Full time  (43) Part time  (1)
Refine by Country
United States  (58)
Refine by City
Cambridge  (28) Boston  (22) Waltham  (4) Somerville  (2) Andover  (1) Lowell  (1)
BM
Principal Scientist Computational Biology
BristolMyers Squibb Cambridge, MA, USA
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . Job Description We seek a creative and passionate computational...

Feb 17, 2026
BM
Full time
 
Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology
Bristol Myers Squibb Careers Cambridge, MA, USA
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more careers.bms.com/working-with-us . The Oncology Thematic Research Center at BMS is a key research and early...

Feb 16, 2026
MI
Full time
 
Principal Scientist, T Cell Immunology (Autoimmunity and Infectious Disease)
Moderna, Inc. Cambridge, MA, USA
The Role Moderna is seeking a talented, experienced, and motivated candidate to lead innovative immunology efforts across autoimmune and infectious disease programs. This role will drive mechanistic discovery and translational immunology to enable antigen-specific and pathway-directed mRNA-LNP therapeutics. The ideal candidate brings deep expertise in T cell biology in the setting of autoimmunity and/or infectious diseases, a strong track record of scientific leadership, and the ability to collaborate effectively across multi-disciplinary teams. Here’s What You’ll Do Lead preclinical research efforts in one or more autoimmune or infectious disease programs from early discovery through IND-enabling studies. Establish preclinical models and perform T cell immune profiling to support target discovery, validation and clinical enablement. Drive translational research to elucidate therapeutic mechanism of action through analysis of human clinical samples. Contribute to...

Feb 13, 2026
Or
Principal scientist cost of cloud
Oracle Boston, MA, USA
Job Description Job Description: Lead AI development from Context Aware Agents, Action Agents to Reasoning Agents, with Multi Agent Orchestration. This will involve strategy and planning through several critical milestones across team of Applied Scientists, Data Engineers and Business Stakeholders. This is a hands on role, requiring coding, testing, delivery and ongoing maintenance and training for solutions in production, as well as fostering business partnership and accountability every step of the way. Lead ML Model Development: Lead the design, development and productionalization of advanced machine learning models for time series and anomaly detection. Responsible for optimizing models to enhance precision, ensuring high performance, accuracy and reliability. Use machine learning, data mining, statistical techniques, and others to create actionable, meaningful, and scalable solutions that drive Cloud Capacity Management and Cost Optimization....

Feb 17, 2026
MI
Full time
 
Principal Scientist, T Cell Immunology (Autoimmunity and Infectious Disease)
Moderna, Inc. Cambridge, MA, USA
The Role: Moderna is seeking a talented, experienced, and motivated candidate to lead innovative immunology efforts across autoimmune and infectious disease programs. This role will drive mechanistic discovery and translational immunology to enable antigen-specific and pathway-directed mRNA-LNP therapeutics. The ideal candidate brings deep expertise in T cell biology in the setting of autoimmunity and/or infectious diseases, a strong track record of scientific leadership, and the ability to collaborate effectively across multi-disciplinary teams. Here’s What You’ll Do: Lead preclinical research efforts in one or more autoimmune or infectious disease programs from early discovery through IND-enabling studies. Establish preclinical models and perform T cell immune profiling to support target discovery, validation and clinical enablement. Drive translational research to elucidate therapeutic mechanism of action through analysis of human clinical samples....

Feb 13, 2026
AT
Associate Scientist / Principal Associate Scientist, Protein Analytics
Alloy Therapeutics Waltham, MA, USA
Feb 17, 2026
Or
Sr Principal Applied Scientist, Cost of Cloud Optimization ML/AI
Oracle Boston, MA, USA
Job Description Job Description: Lead AI development from Context Aware Agents, Action Agents to Reasoning Agents, with Multi Agent Orchestration. This will involve strategy and planning through several critical milestones across team of Applied Scientists, Data Engineers and Business Stakeholders. This is a hands on role, requiring coding, testing, delivery and ongoing maintenance and training for solutions in production, as well as fostering business partnership and accountability every step of the way. Lead ML Model Development: Lead the design, development and productionalization of advanced machine learning models for time series and anomaly detection. Responsible for optimizing models to enhance precision, ensuring high performance, accuracy and reliability. Use machine learning, data mining, statistical techniques, and others to create actionable, meaningful, and scalable solutions that drive Cloud Capacity Management and Cost Optimization....

Feb 17, 2026
Or
Principal Applied Scientist (GenAI)
Oracle Boston, MA, USA
Job Description We are seeking a visionary leader to spearhead image generation model research and development efforts. As the Code Assist generation model scientist lead, you will be responsible for driving the development and implementation of cutting-edge code generation and manipulation technologies. You will lead a team of world-class scientists in exploring new frontiers of code generation for the most popular languages simplifying documentation, unit testing, optimizing existing code, explaining code and simplifying way users interact with the database systems enabling natural language interface. Responsibilities Research and Development: Conduct in-depth research on code generation techniques, including code to code (Java, SQL, Python, etc.), doc to code/code to doc, and other emerging approaches. Model Development: Design, develop, and train state-of-the-art code generation models that meet the highest quality standards. Team Leadership: Build...

Feb 15, 2026
Or
Principal Applied Scientist - OCI/GenAI (Multimodal)
Oracle Boston, MA, USA
Job Description As part of the OCI Multimodal AI Science Team, we are seeking a visionary leader to spearhead image generation model research and development efforts. As the video generation model scientist lead, you will be responsible for driving the development and implementation of cutting-edge video generation and manipulation technologies. You will lead a team of world-class scientists in exploring new frontiers of video synthesis, style transfer, and video editing. Responsibilities Research: Conducting in-depth research on image and video generation techniques, including generative adversarial networks (GANs), diffusion models, and other emerging approaches. Model Development: Designing, developing, and training state-of-the-art generation models that meet the highest quality standards. Team Leadership: Building and mentoring a high-performing team of scientists and engineers to execute on ambitious technical goals. Collaboration:...

Feb 10, 2026
BI
Full time
 
Research Scientist I - The Zhang Lab
Broad Institute Cambridge, MA, USA
General information Location Cambridge, MA Ref # 43643 Job Family Research Workplace On-Site Date published 02/20/2026 Time Type Full time Pay Range $88,000.00/yr - $124,000.00/yr Description & Requirements The Zhang Lab explores and studies biological diversity to understand nature and discover systems and processes that may be harnessed through bioengineering for the improvement of human well-being. We are looking to recruit a sharp, experienced, creative, and independent scientist to lead a project focused on therapeutic cellular engineering. The candidate will pursue his/her own project within the group, collaborating with existing lab members or new hires as needed to advance the project. The Zhang lab is a member of the Broad Institute of MIT & Harvard and McGovern Institute at MIT, and a part of the greater Boston life-science community including MIT and Harvard. Our lab is a fun, fast-paced,...

Feb 23, 2026
AT
Full time
 
Associate Scientist, In Vitro Pharmacology
Alloy Therapeutics Waltham, MA, USA
The Company We are Alloy Therapeutics —a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN. Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful...

Feb 22, 2026
Or
Senior Principal AI Architect
Oracle Boston, MA, USA
Job Description As a Principal Data Scientist, you will play a key role in designing, building, and maintaining the data infrastructure that powers statistical analyses and machine learning initiatives for the Network Reliability Engineering organization. You will work closely with data scientists, engineers, and other stakeholders to develop and deploy scalable, efficient, and reliable ETL data pipelines that drive business value. You will also lead initiatives to improve, deliver, and enable reporting and insights. Responsibilities Design, build, and maintain large-scale ETL data pipelines to support statistical analyses and machine learning model training, testing, and deployment Collaborate with data scientists and other stakeholders to understand data needs and develop effective solutions Create comprehensive data strategies to enable reporting, analytics, and machine learning Conduct research to evaluate data and answer strategic business...

Feb 16, 2026
Or
Senior principal architect
Oracle Boston, MA, USA
Job Description As a Principal Data Scientist, you will play a key role in designing, building, and maintaining the data infrastructure that powers statistical analyses and machine learning initiatives for the Network Reliability Engineering organization. You will work closely with data scientists, engineers, and other stakeholders to develop and deploy scalable, efficient, and reliable ETL data pipelines that drive business value. You will also lead initiatives to improve, deliver, and enable reporting and insights. Responsibilities Design, build, and maintain large-scale ETL data pipelines to support statistical analyses and machine learning model training, testing, and deployment Collaborate with data scientists and other stakeholders to understand data needs and develop effective solutions Create comprehensive data strategies to enable reporting, analytics, and machine learning Conduct research to evaluate data and answer strategic business...

Feb 16, 2026
AT
Full time
 
Scientist I/II, In Vitro Pharmacology
Alloy Therapeutics Waltham, MA, USA
The Company We are Alloy Therapeutics —a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN. Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful...

Feb 12, 2026
BM
Part time
 
Research Scientist, Psychiatry (per diem)
Boston Medical Center Boston, MA, USA
Position: Research Scientist, Psychiatry (Psychosis Care) Location: Boston, MA Schedule: Per Diem ABOUT BMC: At Boston Medical Center (BMC), our diverse staff works together for one goal — to provide exceptional and equitable care to improve the health of the people of Boston. Our bold vision to transform health care is powered by our respect for our patients and our commitment to ensure everyone who comes through our doors has a positive experience. You’ll find a supportive work environment at BMC, with rich opportunities throughout your career for training, development, and growth. POSITION SUMMARY : The Research Scientist supports and leads the implementation, analysis, and dissemination of various research and evaluation projects, with a focus on advising and supervising Community Health Workers (CHWs) engaged in research, evaluation, and programmatic activities. Working collaboratively with Principal Investigators and interdisciplinary...

Feb 07, 2026
Or
Prinicipal Applied Scientist (GenAI)
Oracle Boston, MA, USA
Job Description We are seeking a visionary leader to spearhead image generation model research and development efforts. As the Code Assist generation model scientist lead, you will be responsible for driving the development and implementation of cutting-edge code generation and manipulation technologies. You will lead a team of world-class scientists in exploring new frontiers of code generation for the most popular languages simplifying documentation, unit testing, optimizing existing code, explaining code and simplifying way users interact with the database systems enabling natural language interface. Responsibilities Research and Development: Conduct in-depth research on code generation techniques, including code to code (Java, SQL, Python, etc.), doc to code/code to doc, and other emerging approaches. Model Development: Design, develop, and train state-of-the-art code generation models that meet the highest quality standards. Team Leadership: Build...

Feb 15, 2026
EG
DataStage Data Engineer
Eliassen Group Boston, MA, USA
DataStage Data Engineer Anywhere Type: Contract Category: Engineer Industry: Financial Services Workplace Type: Remote Reference ID: JN -022026-105556 Date Posted: 02/17/2026 Shortcut: http://careers.eliassen.com/icLSeK Description Recommended Jobs Description: Remote Our client is a large U.S. financial institution headquartered in Cincinnati, Ohio. It operates an extensive retail banking network across multiple states and is a principal subsidiary of a major bank holding company. The organization ranks on the Fortune 500 and maintains thousands of ATMs and over a thousand branches. Due to client requirements, applicants must be willing and able to work on a w2 basis. For our w2 consultants, we offer a great benefits package that includes Medical, Dental, and Vision benefits, 401k with company matching, and life insurance. Rate: $64.00 to $74.00/hr. w2 Responsibilities: Responsibilities Design,...

Feb 23, 2026
Liberty Mutual Insurance
Full time
 
Principal Data Solutions Analyst
Liberty Mutual Insurance Boston, MA, USA
Description Working and learning data engineering concepts that relate to data science and insurance. Develop data pipelines for customers across the liberty organization, and utilize various tools such as R, Python, Redshift, SAS, AWS EC2, and Power BI for this purpose. Building all required features and adding them to the pipeline to help data scientists to make their decision making faster. Identifying data quality issues and communicating the associated risks to the stakeholders. Developing ETL data pipelines in Redshift, AWS Glue to eliminate dependency on outdated warehousing system. Automation of whole business scenarios from initial data pipeline building to final prediction making algorithms. Telecommuting permitted up to 100%. Qualifications Employer will accept a bachelor’s degree (or foreign equivalent) in Information Systems, Computer Science, Data Analytics or related field and 5 years of experience in the job offered or in a Principal Data...

Feb 22, 2026
Liberty Mutual Insurance
Full time
 
Principal Data Solutions Analyst
Liberty Mutual Insurance Boston, MA, USA
Description Working and learning data engineering concepts that relate to data science and insurance. Develop data pipelines for customers across the liberty organization, and utilize various tools such as R, Python, Redshift, SAS, AWS EC2, and Power BI for this purpose. Building all required features and adding them to the pipeline to help data scientists to make their decision making faster. Identifying data quality issues and communicating the associated risks to the stakeholders. Developing ETL data pipelines in Redshift, AWS Glue to eliminate dependency on outdated warehousing system. Automation of whole business scenarios from initial data pipeline building to final prediction making algorithms. Telecommuting permitted up to 100%. Qualifications Employer will accept a bachelor’s degree (or foreign equivalent) in Information Systems, Computer Science, Data Analytics or related field and 5 years of experience in the job offered or in a Principal Data Solutions...

Feb 22, 2026
AT
Senior Director, Business Development
Alloy Therapeutics Waltham, MA, USA
The Company We are Alloy Therapeutics-a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN. Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful...

Feb 22, 2026
Liberty Mutual Insurance
Full time
 
Principal data analyst
Liberty Mutual Insurance Boston, MA, USA
Description Working and learning data engineering concepts that relate to data science and insurance. Develop data pipelines for customers across the liberty organization, and utilize various tools such as R, Python, Redshift, SAS, AWS EC2, and Power BI for this purpose. Building all required features and adding them to the pipeline to help data scientists to make their decision making faster. Identifying data quality issues and communicating the associated risks to the stakeholders. Developing ETL data pipelines in Redshift, AWS Glue to eliminate dependency on outdated warehousing system. Automation of whole business scenarios from initial data pipeline building to final prediction making algorithms. Telecommuting permitted up to 100%. Qualifications Employer will accept a bachelor’s degree (or foreign equivalent) in Information Systems, Computer Science, Data Analytics or related field and 5 years of experience in the job offered or in a Principal Data...

Feb 22, 2026
Liberty Mutual Insurance
Full time
 
Principal data analyst
Liberty Mutual Insurance Boston, MA, USA
Description Working and learning data engineering concepts that relate to data science and insurance. Develop data pipelines for customers across the liberty organization, and utilize various tools such as R, Python, Redshift, SAS, AWS EC2, and Power BI for this purpose. Building all required features and adding them to the pipeline to help data scientists to make their decision making faster. Identifying data quality issues and communicating the associated risks to the stakeholders. Developing ETL data pipelines in Redshift, AWS Glue to eliminate dependency on outdated warehousing system. Automation of whole business scenarios from initial data pipeline building to final prediction making algorithms. Telecommuting permitted up to 100%. Qualifications Employer will accept a bachelor’s degree (or foreign equivalent) in Information Systems, Computer Science, Data Analytics or related field and 5 years of experience in the job offered or in a Principal Data Solutions...

Feb 22, 2026
TG
Full time
 
Research Assistant
The General Hospital Corporation Somerville, MA, USA
Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Psychiatry Neuroimaging Laboratory is looking to hire a qualified candidate for the position of Research Assistant. The laboratory is part of the Department of Psychiatry at Massachusetts General Hospital. The main mission of this laboratory is to understand brain abnormalities and their role in psychiatric disorders by using state-of-the-art neuroimaging techniques. If you would like to read more about the laboratory, please visit our website...

Feb 21, 2026
TG
Full time
 
Research Assistant
The General Hospital Corporation Somerville, MA, USA
Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Psychiatry Neuroimaging Laboratory is looking to hire a qualified candidate for the position of Research Assistant. The laboratory is part of the Department of Psychiatry at Massachusetts General Hospital. The main mission of this laboratory is to understand brain abnormalities and their role in psychiatric disorders by using state-of-the-art neuroimaging techniques. If you would like to read more about the laboratory, please visit our...

Feb 21, 2026
  • Home
  • Learn Practical AI Skills
  • Contact
  • About Us
  • Terms & Conditions
  • Industry Training
  • United States
  • Australia
  • Singapore
  • New Zealand
  • Industry Jobs
  • Find Jobs
  • Create Resume
  • Sign in
  • Career Consultation
  • Facebook
  • LinkedIn
© Institute of Data. All rights reserved.